With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
123770-62-7, In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), commercially available 5-hydroxymethyl-isoxazole-3-carboxylic acid ethyl ester (5.00 g, 26.29 mmol) was dissolved in dry THF (200 ml_). te/t-Butyldimethylsilyl chloride (4.04 g, 26.82 mmol) was added at rt followed by imidazole (1.97 g, 28.92 mmol). The reaction mixture was stirred at rt overnight. Sat. aq. NH4CI (150 ml.) was added followed by EA (100 ml.) and the layers were separated. The aq. layer extracted with EA (2 x 100 ml_). The combined org. extracts were dried over MgSO4, filtered, and the solvent removed under reduced pressure. Purification of the residue by FC (9:1 hept-EA) gave the title compound as a light yellow oil: TLC: rf (9:1 hept-EA) = 0.37. LC-MS-conditions 02: tR = 1.14 min; [M+AcCN+H]+ = 327.51.
123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/77990; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem