36958-61-9, 5-(Bromomethyl)-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Sodium hydride (60% w/w) (0.46 g, 1 1 .4 mmol) was added portionwise to a solution of 7-benzylsulfanyl-4-bromo-2H-isoquinolin-1 -one (2.82 g, 8.14 mmol) in DMF (40 mL) at 0 C. After 1 h 5-(bromomethyl)-3-methyl-1 ,2-oxazole (1 .72 g, 9.77 mmol) was added and the mixture stirred at ambient temperature overnight. EtOAc (150 mL) and saturate aq. NaHC03 (150 mL) were added and the mixture stirred for 5 min. The EtOAc layer was separated and the aqueous layer washed with EtOAc (100 mL). The combined organic extracts were passed through a hydrophobic frit, concentrated under reduced pressure and purified by automated column chromatography, eluent 0-100% EtOAc in iso-hexane, yielding 7-benzylsulfanyl-4-bromo-2-[(3-methylisoxazol-5-yl)methyl]isoquinolin-1 -one (1 .78 g, 4.03 mmol,LCMS (high pH): RT 1 .40 min, [M+H]+ 441 .0, 94% purity
36958-61-9, 36958-61-9 5-(Bromomethyl)-3-methylisoxazole 10607354, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; MCGONAGLE, Alison E.; JORDAN, Allan; WASZKOWYCZ, Bohdan; HUTTON, Colin; WADDELL, Ian; HITCHIN, James R.; SMITH, Kate Mary; HAMILTON, Niall M.; (497 pag.)WO2016/92326; (2016); A1;,
Isoxazole – Wikipedia
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