With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4
A mixture of Compound 53 (70 mg, 0.11 mmol), 4-dimethylaminopyridine (30 mg, 0.25 mg), and isoxazole-5-carbonyl chloride (35 muL, 0.22 mmol) in 3.0 mL of dichloromethane was stirred at 21 C. for 5 hours. The reaction was quenched with saturated sodium bicarbonate solution, and aqueous layer was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to afford a crude product, which was chromatographed to give the desired product. 1H NMR (300 MHz, CDCl3): delta 0.23 (s, 6H), 0.74 (m, 2H), 0.97 (m, 5H), 1.82 (m, 2H), 2.22 (m, 2H), 3.12 (m, 2H), 4.35 (t, J=6.9 Hz, 2H), 5.14 (m, 2H), 5.24 (s, 2H), 5.40 (d, J=17.4 Hz, 1H), 5.71 (d, J=17.4 Hz, 1H), 6.98 (d, J=1.8 Hz, 1H), 7.30 (m, 6H), 7.69 (t, J=6.0 Hz, 1H), 7.82 (t, J=8.4 Hz, 1H), 8.05 (d, J=7.8 Hz, 1H), 8.24 (d, J=8.4 Hz, 1H), 8.36 (d, J=1.8 Hz, 1H).
As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.
Reference£º
Patent; BioNumerik Pharmaceuticals, Inc.; US2009/99224; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem