Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3235-67-4, is researched, SMILESS is OC(=O)CN1CCCCC1, Molecular C7H13NO2Journal, Article, Chemistry – An Asian Journal called Hydroxamic Acid-Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions, Author is Mizumoto, Shinsuke; Xi, Siqi; Fujiwara, Yusuke; Kawashima, Shigehiro A.; Yamatsugu, Kenzo; Kanai, Motomu, the main research direction is hydroxamic acid piperidine conjugate catalyst lysine acetylation physiol; acylation; catalyst; hydroxamic acid; lysine acetylation; protein modifications.Safety of 1-Piperidineacetic Acid.
Lysine acylation of proteins is an essential chem. reaction for posttranslational modification and as a means of protein modification in various applications. N,N-Dimethyl-4-aminopyridine (DMAP) derivatives are widely-used catalysts for lysine acylation of proteins; however, the DMAP moiety mostly exists in a protonated, and thus deactivated, form under physiol. conditions due to its basicity. An alternative catalytic motif furnishing higher acylation activity would further broaden the possible applications of chem. lysine acylation. We herein report that the hydroxamic acid-piperidine conjugate Ph-HXA is a more active catalytic motif for lysine acetylation than DMAP under physiol. conditions. In contrast to DMAP, the hydroxamic acid moiety is mostly deprotonated under aqueous neutral pH, resulting in a higher concentration of the activated form. The Ph-HXA catalyst is also more tolerant of deactivation by a high concentration of glutathione than DMAP. Therefore, Ph-HXA might be a suitable catalytic motif for target protein-selective and site-selective acetylation in cells.
After consulting a lot of data, we found that this compound(3235-67-4)Safety of 1-Piperidineacetic Acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem