With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87988-94-1,5-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.
87988-94-1, A mixture of 2-{[(4-f.uorop enyl)methyl]oxy}-5-(1-methyl-1 H-pyrazol-4-yl)benzoic acid (may be prepared as described in Description 121 ; 80 mg, 0.25 mmol), 3- methylisoxazol-4-amine (49.5 mg, 0.37 mmol), HOBT (56.3 mg, 0.37 mmol) and EDC (70.5 mg, 0.37 mmol) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 16 hours. Water (50 ml) was added. A white precipitate was filtered, washed with ethyl acetate, and dried in vacuo to yield the title compound as a white solid. 54 mg, 1HNMR (400 MHz, DMSO-c 6): 1 .99 (3H, s), 3.86 (3 H, s), 5.25 (2 H, s), 7.25 (2H, t, J= 8.8 Hz), 7.32 (2H, d, J = 8.4 HZ), 7.59-7.62 ( H, q, J = 2.8, J = 8.8), 7.73-7.75 ( H, dd, J = 2.4 Hz, J = 8.4 Hz), 7.88 (1 H, s), 7.92 (1 H, d, J = 2.4), 8.16 (1 H, s), 9.17 (1 H, s), 9.88 (1 H, s)MS (electrospray): m/z [M+H]+ =407.1
As the paragraph descriping shows that 87988-94-1 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem