Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Trimethylphosphineoxide, is researched, Molecular C3H9OP, CAS is 676-96-0, about Phosphonium Phenolate Zwitterion vs. Phosphonium Ylide: Synthesis, Characterization and Reactivity Study of a Trimethylphosphonium Phenolate Zwitterion.COA of Formula: C3H9OP.
4-Methoxy-3-(trimethylphosphonio)phenolate was obtained from a regioselective addition of PMe3 to p-quinone monoacetal. This compound undergoes hydrogen isotope exchange with D2O or CD3CN, and is capable of catalyzing H/D exchange of CD3CN with substrates bearing weakly acidic hydrogens. It exhibits similar reactivity to phosphorus ylides for olefinations of aldehydes. A possible tautomerization between the phosphonium phenolate zwitterion and phosphonium ylide is proposed for the first time to rationalize the unique reactivity.
This literature about this compound(676-96-0)COA of Formula: C3H9OPhas given us a lot of inspiration, and I hope that the research on this compound(Trimethylphosphineoxide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem