With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4
General procedure: Compound 12a (0.05mmol, 20mg) and DIEA (0.075mmol, 9.75mg) were dissolved in 0.5mL of DMF and cooled to 0C, then propionyl chloride (0.06mmol, 5.5mg) was added to the system and the mixture was stirred at 0C for 1h. The system was extracted with EtOAc and dried with anhydrous Na2SO4. The solvents were removed under vacuum and the residue was purified by silica gel flash chromatography (DCM: MeOH=15: 1) to afford compound 13a (15mg, yield 65%).
As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.
Reference£º
Article; Wang, Qiang; Liu, Feiyang; Qi, Shuang; Qi, Ziping; Yan, Xiao-E.; Wang, Beilei; Wang, Aoli; Wang, Wei; Chen, Cheng; Liu, Xiaochuan; Jiang, Zongru; Hu, Zhenquan; Wang, Li; Wang, Wenchao; Ren, Tao; Zhang, Shanchun; Yun, Cai-Hong; Liu, Qingsong; Liu, Jing; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 366 – 384;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem