With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288-14-2,Isoxazole,as a common compound, the synthetic route is as follows.
Step 4. Preparation of 4-[3-methyl-5-(3-chlorophenyl)isoxazol-4-yl]benzenesulfonamide Following the procedure of Example 14, Step 4, the isoxazole from Step 3 (2 g, 7.4 mmol) was reacted with chlorosulfonic acid (8 mL) and quenched with ammonium hydroxide. The crude product was recrystallized from ethyl acetate to give pure sulfonamide (220 mg): mp 176-178 C. Anal. Calc’d. for C16 H13 ClN2 O3 S (348.81): C, 55.10; H, 3.76; N, 8.03; S, 9.19. Found: C, 54.60; H, 3.63; N, 7.77; S, 9.21.
As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.
Reference£º
Patent; G. D. Searle & Co.; US5859257; (1999); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem