Tag: 288-14-2

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00458] Intermediate 46 : Synthesis of 3-(isoxazol-4-yl)benzaldehyde: [00459] Step 1: Synthesis of 4-iodoisoxazole: To a solution of NIS (23.0 g, 100 mmol) in TFA (200 mL) was added isoxazole (6.9 g, 100 mmol) in one portion at room temperature and the resultant mixture was stirred for 18 h. The mixture was partitioned between PE (200 mL) and water (1000 mL). The organic phase was separated and washed with saturated sodium bisulfate, dried with anhydrous Na2S04, filtered and concentrated to give a yellow solid (1.2 g, 7%).

288-14-2 Isoxazole 9254, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WO2011/38204; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288-14-2,Isoxazole,as a common compound, the synthetic route is as follows.

Step 4. Preparation of 4-[3-methyl-5-(3-chlorophenyl)isoxazol-4-yl]benzenesulfonamide Following the procedure of Example 14, Step 4, the isoxazole from Step 3 (2 g, 7.4 mmol) was reacted with chlorosulfonic acid (8 mL) and quenched with ammonium hydroxide. The crude product was recrystallized from ethyl acetate to give pure sulfonamide (220 mg): mp 176-178 C. Anal. Calc’d. for C16 H13 ClN2 O3 S (348.81): C, 55.10; H, 3.76; N, 8.03; S, 9.19. Found: C, 54.60; H, 3.63; N, 7.77; S, 9.21.

As the paragraph descriping shows that 288-14-2 is playing an increasingly important role.

Reference£º
Patent; G. D. Searle & Co.; US5859257; (1999); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem