With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.
General procedure: The heterocyclic amines (1a-h, 10 mmol) were dissolved in 10 mL water followed by addition of 40 mL of 6M HCl and the systems were cooled in the ice-salt bath down to -10C. Afterwards, an aqueous solution of NaNO2 (10 mmol, 0.7g/5 mL H2O) was added slowly drop by drop and stirred vigorously on a magnetic stirrer. After 15 min, fresh solution of 4-hydroxycoumarin (3, 10 mmol, 1.62 g) in 10 mL NaOH (10 wt.) was added. Intensively colored and voluminous precipitates (4a-h) were obtained immediately which were stirred 15 min. in the bath and 30 min. on room temperature. Finally, they were filtrated by vacuum, washed 3 times with distilled water and dried on air. The purification was carried out by the technique of recrystallization using ethanol as solvent.
1750-42-1, As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.
Reference£º
Article; Jashari, Ahmed; Imeri, Faik; Ballazhi, Lulzime; Shabani, Agim; Mikhova, Bozhana; Draeger, Gerald; Popovski, Emil; Huwiler, Andrea; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2655 – 2661;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem