Martin, Rainer E. published the artcileBenzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists, Related Products of isoxazole, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6106-6113, database is CAplus and MEDLINE.
SAR studies of a recently described SST5R selective benzoxazole piperidine I lead series are described with particular focus on the substitution pattern on the benzyl and benzoxazole side-chains. Introduction of a second meta substituent at the benzyl unit significantly lowers residual hH1 activity and insertion of substituents onto the benzoxazole periphery entirely removes remaining h5-HT2B activity. Compounds with single digit nM activity, functional antagonism and favorable physicochem. properties endowed with a good pharmacokinetic profile in rats are described which should become valuable tools for exploring the pharmacol. role of the SST5 receptor in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about 54120-91-1. 54120-91-1 belongs to isoxazole, auxiliary class Chloride,Nitro Compound,Benzooxazole, name is 2-Chloro-5-nitrobenzoxazole, and the molecular formula is C7H3ClN2O3, Related Products of isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem