Kerr, William J. published the artcileIridium-catalysed ortho-H/D and -H/T exchange under basic conditions: C-H activation of unprotected tetrazoles, Application In Synthesis of 2251-79-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(40), 6669-6672, database is CAplus and MEDLINE.
The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles I (X = 4-MeO, 2-Me, 3-Cl, etc.) are described. A new base-assisted protocol for iridium(I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles, e.g., II, including the tetrazole-containing pharmaceutical, Valsartan. Preliminary mechanistic studies are also presented.
Chemical Communications (Cambridge, United Kingdom) published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Application In Synthesis of 2251-79-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem