Andersen, Jacob Lauwring’s team published research in Bioorganic & Medicinal Chemistry Letters in 27 | CAS: 1076-59-1

Bioorganic & Medicinal Chemistry Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, SDS of cas: 1076-59-1.

Andersen, Jacob Lauwring published the artcileThe identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin, SDS of cas: 1076-59-1, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(11), 2629-2633, database is CAplus and MEDLINE.

Using fragment based and structure based drug discovery strategies a series of novel Sortilin inhibitors has been identified. The inhibitors are based on the N-substituted 1,2,3-triazol-4-one/ol heterocyclic template. X-ray crystallog. shows that the 1,2,3-triazol-4-one/ol acts as a carboxylic acid isostere, making a bi-dentate interaction with an arginine residue of Sortilin, an interaction which has not been previously characterized for this heterocycle.

Bioorganic & Medicinal Chemistry Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, SDS of cas: 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem