In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The hydrophobic side chain of oseltamivir influences type A subtype selectivity of neuraminidase inhibitors, published in 2018-01-31, which mentions a compound: 3235-67-4, mainly applied to oseltamivir hydrophobicity neuraminidase inhibitor influenza; anti-influenza; neuraminidase inhibitors; oseltamivir derivatives; selectivity, Recommanded Product: 3235-67-4.
Neuraminidase, which plays a critical role in the influenza virus life cycle, is a target for new therapeutic agents. The study of structure-activity relationships revealed that the C-5 position amino group of oseltamivir was pointed to 150-cavity of the neuraminidase in group 1. This cavity is important for selectivity of inhibitors against N1 vs. N2 NA. A serial of influenza neuraminidase inhibitors with the oseltamivir scaffold containing lipophilic side chains at the C-5 position have been synthesized and evaluated for their influenza neuraminidase inhibitory activity and selectivity. The results indicated that compound 13o (H5N1 IC50 = 0.1 ± 0.04 μm, H3N2 IC50 = 0.26 ± 0.18 μm) showed better inhibitory activity and selectivity against the group 1 neuraminidase. This study may provide a clue to design of better group 1 neuraminidase inhibitors.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Piperidineacetic Acid)Recommanded Product: 3235-67-4, illustrating the importance and wide applicability of this compound(3235-67-4).
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem