2510-36-3, In an article, published in an article,authors is Chang, Shaohua, once mentioned the application of 2510-36-3, Name is 3,5-Dimethylisoxasole-4-carboxylic acid,molecular formula is C6H7NO3, is a conventional compound. this article was the specific content is as follows.
Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-beta type 1 receptor inhibitors
Inhibition of transforming growth factor beta (TGF-beta) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-beta type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem