HPLC of Formula: 3235-67-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Piperidineacetic Acid, is researched, Molecular C7H13NO2, CAS is 3235-67-4, about MNDO study of the preparation of substituted aminoacetate of 3-hydroxy-1,4-benzodiazepine. Author is Yao, Chunfang; Jiao, Kefang.
The esterification of 3-hydroxy-1,4-benzodiazepine(A1) with chloroacetyl chloride produced 3-hydroxy-1,4-benzodiazepine chloroacetate(A2). The authors tried to obtain substituted aminoacetate of 3-hydroxy-1,4-benzodiazepine(A3) by reacting A2 with secondary amines, but only A1 was obtained. In order to find out why the reaction yielded A1 but not A3, A2 was calculated with MNDO(modified NDDO) program. The amination mechanism was discussed with the perturbation theory of the frontier orbitals. The results showed that the effect of the frontier orbital was insignificant and the effect of the charge was significant when the reaction took place. In the amination, the yield was about 60% at the carbonyl carbon atom and only 30%-40% at the chloroalkyl carbon atom, theor. Therefore, the amination of the chloroacetate (A2) for preparing the substituted aminoacetate is probably not suitable. Finally, A3 was obtained by the esterification of A1 with the N,N-substituted aminoacetic acid in the presence of the catalyst.
This literature about this compound(3235-67-4)HPLC of Formula: 3235-67-4has given us a lot of inspiration, and I hope that the research on this compound(1-Piperidineacetic Acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem