51677-09-9,51677-09-9, Methyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a stirred solution of substrate 1 (1.0 equiv) in THF (0.2 M) was added Grignardreagent (5.0 equiv) or organolithium reagent (2.0 or 3.0 equiv) at -78 C and the resulting solution wasstirred at the same temperature under Ar. After the substrate 1 was consumed or the reaction did not proceedany more (judged by TLC), sat. NH4Cl aq. was added to the reaction mixture and the resultingsolution was warm to rt and extracted with AcOEt. The combined organic layer was dried overNa2SO4 and concentrated in vacuo. The crude product was purified by flash column chromatography onsilica gel.p-Fluorophenylmagnesium chloride was prepared form p-fluoroiodobenzene and iPrMgCl according to theliterature.4Organolithium reagents were prepared by adding n-butyl lithium (hexane solution, 1.0 equiv) to a solution ofalkyne (1.1 equiv) in THF (0.8M) at -78 C and stirring at rt for 1 h.
As the paragraph descriping shows that 51677-09-9 is playing an increasingly important role.
Reference£º
Article; Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi; Tetrahedron Letters; vol. 53; 29; (2012); p. 3746 – 3749;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem