With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.
To a solution of 2-(2,4-dimeihyiphenyl)-A’-(4-hydroxybenzyl)-2-phenylaceiamide (0.06 g,0.17 mmol) in acetonitrile (3 mL) was added cesium carbonate (0. 7 g, 0.52 mmol) and 4- (chloromethy])-3,5-dimethyfisoxazofe (0,03 g, 0.21 mmol). The resulting mixture was heated at 70 C and stirred for 2 h in a sealed-tube. After completion of the reaction, water ( 10 mL) was added, and ihe mixture was extracted with ethyl acetate (2 x 15 mL). The combined organic layers were dried over a2S04 and evaporated under vacuum to obtain crade product which was purified by preparatory TLC on silica gel to provide the title compound (50, 1 mg, 63.57%) ]H NMR (400 MHz, DMSO-d6) delta ppm 8.61-8.64 (s, 1 H), 7.26-7.30 (t, 2 H), 7.14-7.23 (m, 5 H), 5.08 is, 1 H), 4.88 (s, 2 H), 4.21-4.24 (t, 2 H), 2.38 (s, 3 H), 2.15-2.22 (i, 9 H).
19788-37-5, The synthetic route of 19788-37-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19635; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem