110256-15-0, 5-Cyclopropylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 5-cyclopropylisoxazole-3-carboxylic acid (50 mg, 0.32 mmol) in DMF (1 mL) was added HATU (120 mg, 0.32 mmol) under N2, the mixture was stirred for 30 mm, then c/s-i[5 -[3 -(trifluoromethoxy)cyclobutylj -1,3 ,4-oxadiazol-2-yl Ibicyclo [1.1.1 jpentan-3 -amine hydrochloride (8:1 to 10:1 favoring the cis- diastereomer) (89 mg, 0.27 mmol) and DIEA (140 mg, 1.1 mmol) were added to the solution at 0 C. The reaction mixture was stirred at 20 C for 12 h. The reaction mixture was quenched by addition of H20 (10 mL) at 0 C and extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with brine (10 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The cmde reaction mixture was purified employing reverse- phase HPLC. LC-MS, mlz = 425.3 [M+Hfb. ?H-NMR (400 MHz, CDC13): 7.25 (s, 1H), 6.32 (s, 1H), 4.71 (quin, J= 7.56 Hz, 1H), 3.40-3.26 (m, 1H), 2.94-2.81 (m, 2H), 2.74-2.69 (m, 2H), 2.686H), 2.15-2.03 (m, 1H), 1.19-1.08 (m, 2H), 1.03-0.94 (m, 2H).
110256-15-0, As the paragraph descriping shows that 110256-15-0 is playing an increasingly important role.
Reference£º
Patent; DENALI THERAPEUTICS INC.; CRAIG, Robert A., II; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; HALE, Christopher R. H.; LEXA, Katrina W.; OSIPOV, Maksim; REMARCHUCK, Travis; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (187 pag.)WO2019/32743; (2019); A1;,
Isoxazole – Wikipedia
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