108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of methyl 2-(5-formyl-2-((2,2,2- trifluoroethyl)amino)pyrimidin-4-yl)-2-(4-methoxyphenyl)acetate (as prepared in General procedure III , Step G) (76 mg, 0.2 mmol, 1.0 equiv), isoxazol-4- amine (42 mg, 0.5 mmol, 2.5 equiv) in DCE/MeOH (3/0.5 mL) was added HOAc (42 mg, 0.7 mmol, 3.5 equiv). The mixture was stirred at 45 C overnight, then the mixture was cooled down to 0C, NaBH3CN (12 mg, 0.2 mmol, 1.0 equiv) was added to the reaction mixture in one portion, after which the resulting mixture was allowed to warm to room temperature and stirred for an additional l2h before being quenched with DCM (10 mL) and H2O (10 mL). The aqueous layer was extracted with DCM (10 mL x 3). The combined organic layers were dried over Na2S04 and concentrated. The residue was purified by Prep-TLC (PE:EA = 1/2) to give 6-(isoxazol-4-yl)-8-(4-methoxyphenyl)-2-((2,2,2- trifluoroethyl)amino)-5,6-dihydropyrido[-/, 3-6/]pyrimidin-7(-/r///)-one (51 mg, 44% yield) as a white solid. LC-MS: m/z 420 [M+H]+., 108511-97-3
As the paragraph descriping shows that 108511-97-3 is playing an increasingly important role.
Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; LI, Mingzong; LIU, Peng; MEDEIROS, Matthew; REZNIK, Samuel K.; SUI, Zhihua; TRAVINS, Jeremy M.; POPOVICI-MULLER, Janeta; ZHOU, Shubao; MA, Guangning; (298 pag.)WO2019/191470; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem