62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.
Compound 6 (14.21g, 30.39mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazol-5-carboxylic acid chloride (35mmol), stirring the reaction was warmed to reflux.After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.After the reactionsolution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(diphenyl[b,d]thiophen-3-yl)-7-) Oxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 15.73 g,yield 92%.
The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zeng Qingqiang; (12 pag.)CN108586445; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem