Unusual Approach to Branched 3-Alkynylamides and to 1,5-Dihydropyrrol-2-ones was written by Dias-Jurberg, Igor;Gagosz, Fabien;Zard, Samir Z.. And the article was included in Organic Letters in 2010.Name: Methyl 2-(5-oxo-4,5-dihydroisoxazol-3-yl)acetate The following contents are mentioned in the article:
Rare carboxamide branched alkynes, such as I, can be readily obtained by reaction of the electrophilic 4-alkylidene isoxazolinones, e.g. II, with isocyanides, e.g. t-BuNC, followed by nitrosative cleavage of the heterocyclic ring. N-Iodosuccinimide-induced ring closure of these alkynamides in the presence of a nucleophile results in the formation of new iodopyrrolinones, such as III (R = H, Me, H2C:CHCH2). This study involved multiple reactions and reactants, such as Methyl 2-(5-oxo-4,5-dihydroisoxazol-3-yl)acetate (cas: 96530-57-3Name: Methyl 2-(5-oxo-4,5-dihydroisoxazol-3-yl)acetate).
Methyl 2-(5-oxo-4,5-dihydroisoxazol-3-yl)acetate (cas: 96530-57-3) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Name: Methyl 2-(5-oxo-4,5-dihydroisoxazol-3-yl)acetate
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem