Deng, Fen published the artcileApplication effect of parecoxib sodium on postoperative analgesia in patients with craniotomy, SDS of cas: 198470-85-8, the publication is Liaoning Yixueyuan Xuebao (2016), 37(4), 61-64, database is CAplus.
Objective: To explore the application effect of parecoxib sodium on postoperative analgesia in patients with craniotomy. Methods: 90 cases of patients who underwent craniotomy in the neurosurgery department of our hospital from Feb. 2014 to Jan. 2015 were selected and randomly divided into the control group and the observation group, with 45 patients in each group. The patients in the observation group were treated with i.v. injection of parecoxib sodium, while the patients in the control group were given the equal amount of normal saline. The heart rate (HR), respiratory frequency (RR) and mean arterial pressure (MAP) in two groups were monitored by professional medical staff before the operation and 1, 6, 12, 24 h after the operation, and the VAS score, the restless score (RS score) and the sedation score (Ramsay score) in two groups were investigated 1, 6, 12 and 24 h after operation. The complications of all patients, 24 h after operation, were statistically analyzed. Results: The levels of HR and MAP in the two groups 1h and 6h after operation were significantly higher than those before operation, while the levels of HR and MAP in the observation group 1h and 6h after operation were significantly lower than those in the control group. The differences were statistically significant (P<0.05). The levels of HR and MAP in the two groups 12 h and 24 h after operation were not significantly different from those before operation (P>0.05). In addition, the level of RR in the two groups 1, 6, 12 and 24 h after operation was not significantly different from that before operation (P>0.05). The VAS and RS scores in the observation group were significantly lower than those in the control group 1, 6, 12 and 24 h after operation, whereas the Ramsay score was significantly higher than that in the control group. The differences were statistically significant (P<0.05). There were no significant differences in the VAS, RS and Ramsay scores in the two groups at each time point after operation (P>0.05). The incidence of complications in the observation group was significantly lower than that in the control group (χ2=1.984, P<0.05). Conclusion: Parecoxib sodium has analgesic and sedative effect on patients after craniotomy, which can improve the postoperative vital signs and reduce the incidence of complications of patients.
Liaoning Yixueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, SDS of cas: 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
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