The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dibromo-1-propanol( cas:96-13-9 ) is researched.SDS of cas: 96-13-9.Rmedi, Hamdi published the article 《Design and synthesis of fused cyclic sulfamides-oxazolidinones》 about this compound( cas:96-13-9 ) in Tetrahedron. Keywords: sulfamoyloxazolidinone preparation; carboxylsulfamide preparation kinetic intramol cyclization. Let’s learn more about this compound (cas:96-13-9).
An efficient protocol for the synthesis of a new series of oxazolidin-2-ones containing sulfamide moieties I (R = Pr, cyclopentyl, Ph, benzyl, etc.) is described. The synthesis was achieved in two reaction steps. The first was carried out under anhydrous conditions at 0 °C through a selective addition of 2,3-dibromopropanol and primary amines RNH2 to chlorosulfonylisocyanate to produce N-carboxylsulfamides RNHS(O)2NHC(O)OCH2CH(Br)CH2Br in good yields. Under appropriate conditions of solvent, base and temperature, these intermediates underwent subsequent intramol. cyclization, giving exclusively the corresponding sulfamoyloxazolidinones.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem