Application of 88-14-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 88-14-2, Name is Furan-2-carboxylic acid, SMILES is O=C(C1=CC=CO1)O, belongs to Isoxazoles compound. In a article, author is Zhao, Zhongkui, introduce new discover of the category.
Simple primary amine catalyzed aerobic reductive ring-cleavage of isoxazole motif
A clean and highly efficient catalytic aerobic reductive ring-cleavage of 3-methylanthra[1,2-c]isoxazole-6,11-dione to 1-amino-2-acetylanthraquinone was performed using simple organic amines as organocatalysts and water as a green reaction medium. This method provides a new clean transformation of isoxazole-containing compounds to the corresponding ortho-amino ketones. The catalytic performance of various organic amines was carefully screened, and simple organic primary amines were found to be promising practical catalysts with outstanding catalytic performance. Isopropylamine as the organocatalyst gave 97.2% conversion of 3-methylanthra[1,2-c]isoxazole-6,11-dione, with 97.2% selectivity to 1-amino-2-acetylanthraquinone, in the presence of oxygen only, using 1 equiv. of hydrazine hydrate at room temperature for 3 h. A possible mechanism is also proposed. (C) 2015, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
Application of 88-14-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88-14-2 is helpful to your research.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem