3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of isoxazole-3-carboxylic acid (28 mg, 0.223 mmol), HATU (84 mg, 0.223 mmol), triethylamine (95 ul, 0.67 mmol) and catalytic amount of DMAP in THF (2 mL) was stirred at room temperature for 5 minutes. 4-(benzo[d]oxazol-2-yl)-3-methylaniline (50 mg, 0.223 mmol) was added and the resulting mixture was stirred at 65 C for 18 h. The reaction mixture was diluted with DCM, washed with saturated solution of NaHCO3 and brine. The organic solution was, dried over Na2SO4, decanted and evaporated under reduced pressure. The crude was purified by column chromatography on silica gel using 1:4 to 1:2 EtOAc:Hexane as mobile phase to give N-(4- (benzo[d]oxazol-2-yl)-3-methylphenyl)isoxazole-3-carboxamide (18 mg, 24%). UPLC-MS (Acidic Method, 4 min): rt 2.01 min, m/z 320.1 [M+H]+ 1H NMR (400 MHz, DMSO-d6) d ppm 10.58-11.34 (m, 1H), 8.95-9.42 (m, 1H), 8.16 (br d, J=8.2 Hz, 1H), 7.65-8.01 (m, 4H), 7.27-7.56 (m, 2H), 7.07 (br d, J=1.8 Hz, 1H), 2.67-2.86 (m, 3H)
3209-71-0, The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R.; GRAHAM, Mark; (46 pag.)WO2020/43880; (2020); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem