206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: Preparation of 3-(4-bromophenyl)-5-(methoxymethyl)isoxazoIe (llf)3-(4-bromophenyl)isoxazol-5-yl)methanol (5.0 g, 19.7 mmol) synthesized in Step 1 of Preparation Example 7, and 60% sodium hydride (1 g) were added to N,N-dimethylformamide (50 niL) and the mixture was stirred for 15 min. After methyl iodide was added thereto and completion of the reaction was confirmed by TLC, extraction was carried out with water (20 mL) and ethyl acetate (100 niL). The organic layer was washed with water (50 mL X 2) and brine (20 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove methylene chloride. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound 3-(4-bromophenyl)-5-(methoxymethyl)isoxazole (l lf). Yield: 95%.1H NMR(CDCl3, 400MHz): 7.67(d, 2H, J=7.2Hz), 7.58(d, 2H, J=7.6Hz), 6.53(s, IH), 4.57(s, 2H), and 3.45(s, 3H)., 206055-91-6
The synthetic route of 206055-91-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DONG-A PHARM. CO., LTD.; YUHAN CO., LTD.; WO2008/108602; (2008); A1;,
Isoxazole – Wikipedia
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