Tag: 206055-91-6

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of 3-(4-bromophenyl)-5-(methoxymethyl)isoxazoIe (llf)3-(4-bromophenyl)isoxazol-5-yl)methanol (5.0 g, 19.7 mmol) synthesized in Step 1 of Preparation Example 7, and 60% sodium hydride (1 g) were added to N,N-dimethylformamide (50 niL) and the mixture was stirred for 15 min. After methyl iodide was added thereto and completion of the reaction was confirmed by TLC, extraction was carried out with water (20 mL) and ethyl acetate (100 niL). The organic layer was washed with water (50 mL X 2) and brine (20 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove methylene chloride. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound 3-(4-bromophenyl)-5-(methoxymethyl)isoxazole (l lf). Yield: 95%.1H NMR(CDCl3, 400MHz): 7.67(d, 2H, J=7.2Hz), 7.58(d, 2H, J=7.6Hz), 6.53(s, IH), 4.57(s, 2H), and 3.45(s, 3H)., 206055-91-6

The synthetic route of 206055-91-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DONG-A PHARM. CO., LTD.; YUHAN CO., LTD.; WO2008/108602; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1,1′-ferrocenedicarboxylic acid (0.274 g, 1.0 mmol) and DCC (0.452 g, 2.2 mmol) were added into a 25 mL one necked round bottom flask with 5 mL dry THF. The mixture was stirred in a cold bath and protected under nitrogen for about 10 min. Then DMAP (0.28 g, 2.2 mmol) in 5 mL dry THF was added to the reaction system using a syringe, the mixture was stirred in the cold bath for an additional 30 min. Subsequently, 2.0 mmol 2a in 5 mL THF was added dropwise to the reaction system using a syringe, at that time, the temperature was maintained at room temperature. After the completion of the reaction monitored by thin layer chromatography (TLC), the reaction mixture was evaporated under reduced pressure, and the residual was directly purified by column chromatography on silica gel with elution by petroleum ether and ethyl acetate (5:1?2:1). Fractions with similar Rf values were combined and vacuum distilled to obtainthe desired compound 3a.

206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Article; Yong, Jianping; Yang, Mingxue; Lu, Canzhong; Wu, Xiaoyuan; Letters in drug design and discovery; vol. 15; 11; (2018); p. 1141 – 1146;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem