With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 3,5-dimethylisoxazole-4-carboxylic acid (8c, 2.0 g, 14.17 mmol) in THF (50 mL) was added N,O-dimethylhydroxylamine hydrochloride (4.25 g, 43.61 mmol), HATU (16.6 g, 43.66 mmol) and DIPA (36.9 g, 118.98 mmol). The reaction mixture was stirred at room temperature overnight. After the reaction was completed, water was added and the aqueous layer was extracted with ethyl acetate (50 mL ¡Á 4). The organic layer was dried over sodium sulfate, and concentrated. The crude product was chromatographed on silica gel to give compound 9c (2.2 g, 84%)., 2510-36-3
The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chang, Shaohua; Guo, Zhuang; Li, Xue; Sun, Tianwen; Wang, Hai; Wang, Xiaowei; Wang, Yazhou; Xu, Guofeng; Xu, Tianwei; Yu, Wenying; Yu, Zhuangzhuang; Zhang, Yan; Zhao, Liwen; European Journal of Medicinal Chemistry; vol. 198; (2020);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem