206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 1,1′-ferrocenedicarboxylic acid (0.274 g, 1.0 mmol) and DCC (0.452 g, 2.2 mmol) were added into a 25 mL one necked round bottom flask with 5 mL dry THF. The mixture was stirred in a cold bath and protected under nitrogen for about 10 min. Then DMAP (0.28 g, 2.2 mmol) in 5 mL dry THF was added to the reaction system using a syringe, the mixture was stirred in the cold bath for an additional 30 min. Subsequently, 2.0 mmol 2a in 5 mL THF was added dropwise to the reaction system using a syringe, at that time, the temperature was maintained at room temperature. After the completion of the reaction monitored by thin layer chromatography (TLC), the reaction mixture was evaporated under reduced pressure, and the residual was directly purified by column chromatography on silica gel with elution by petroleum ether and ethyl acetate (5:1?2:1). Fractions with similar Rf values were combined and vacuum distilled to obtainthe desired compound 3a.
206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Article; Yong, Jianping; Yang, Mingxue; Lu, Canzhong; Wu, Xiaoyuan; Letters in drug design and discovery; vol. 15; 11; (2018); p. 1141 – 1146;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem