With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87988-94-1,5-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.
To a solution of 4-amino-5-methylisoxazole (2.00 g, 20.39mmol; CASNo. 87988-94-1 ) in THF (50 mL) at 0 C was added pyridine (1.65 mL, 20.39 mmol) followed by phenyl chloroformate (2.81 mL, 22.43 mmol). After stirring at 0 0C for 2.5 h, the reaction was warmed to room temp overnight. The reaction was diluted with ethyl acetate and washed with 2M HCI, water, saturated sodium bicarbonate, and brine. The organic layer was dried over magnesium sulfate, filtered, concentrated, and purified by flash chromatography (ethyl acetate (5% ethanol)/ heptanes) to give the title compound as a white solid (2.85 g, 13.07 mmol, 64%).
The synthetic route of 87988-94-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER INC.; WO2009/127948; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem