Brief introduction of 3209-71-0

The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.

3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Cis)-4-phenyldecahydroquinolin-4-ol (enantiomer A, 100 mg, 0.432 mmol), isoxazole-3- carboxylic acid (63.5 mg, 0.562 mmol), EDC (108 mg, 0.562 mmol), HOAt (1.124 ml, 0.5 M in DMF, 0.562 mmol), and TEA (0.078 ml, 0.562 mmol) were combined in DMF (2 ml) at RT. After 16 hr the mixture was filtered using a 0.45 mum PTFE syringe filter and concentrated. The residue was purified by preparative reversed-phase HPLC on a Waters Sunfire column (20×150 mm, 5mum) with gradient elution using 5-70% CH3CN/water containing 0.1% TFA over 20 minutes. Fractions containing the product were pooled and concentrated to give the title compound as an off-white solid (72 mg, 51%).

The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2008/88744; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem