Zu, Bing published the artcileCatalytic Enantioselective Construction of Chiroptical Boron-Stereogenic Compounds, Product Details of C24H22N2O2, the publication is Journal of the American Chemical Society (2021), 143(39), 16302-16310, database is CAplus and MEDLINE.
The construction of main group heteroatom-stereogenic compounds is of great importance due to their intriguing chem., phys., biol., and stereoelectronic properties. Despite that organoboron compounds are widely used in organic chem., the creation of a tetrahedral B-stereogenic center in one enantiomeric form remains highly challenging. Given the labile nature of ligands attached to the tetracoordinate B atom, only a handful of enantioenriched B-stereogenic compounds are reported via resolution or a chiral substrate-induced diastereoselective approach. To date catalytic asym. synthesis of B-stereogenic compounds has remained unknown. Here, the authors demonstrate the 1st catalytic enantioselective construction of B-stereogenic compounds via an asym. Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. This enantioselective CuAAC reaction not only gives access to a wide range of novel highly functionalized B-stereogenic heterocycles in high yields with good to excellent enantioselectivities but also produces optically active terminal alkyne and triazole moieties with various potential application prospects. Further transformation of the chiral tetracoordinate B compounds delivers several complex heterocyclic entities bearing B-stereogenic centers without the loss of enantiopurity. Also, the x-ray structure, the barrier to racemization, and the HOMO/LUMO gap of selected tetracoordinate B compounds were studied. Notably, these novel N,N π-conjugated B-stereogenic compounds exhibit bright fluorescence. The optical properties, including CD, quantum yield, and circular polarized luminescence spectroscopies, were examined These features expand the chem. space of the chiroptical B-based dye platform, which could have great potential applications in chiral optoelectronic materials.
Journal of the American Chemical Society published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C7H10BNO3, Product Details of C24H22N2O2.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem