Zhu, Yang-Zi published the artcileParecoxib prevents early postoperative cognitive dysfunction in elderly patients undergoing total knee arthroplasty: A double-blind, randomized clinical consort study, Product Details of C19H17N2NaO4S, the publication is Medicine (Philadelphia, PA, United States) (2016), 95(28), e4082, database is CAplus and MEDLINE.
Background: Trial design neuroinflammation and postoperative pain after surgery are increasingly reported in association with postoperative cognitive dysfunction (POCD). Parecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for postoperative analgesia for its potent anti-inflammatory and analgesic effects. This study aimed to evaluate parecoxib’s effects on POCD in elderly patients undergoing total knee arthroplasty. Methods: Around 134 elderly patients undergoing total knee arthroplasty were randomly divided into parecoxib (group P) and control (groupC) groups, and treated with parecoxib sodium and saline, resp., shortly after induction of general anesthesia and 12-h postsurgery, resp. Perioperative plasma IL-1β, IL-6, TNF-α, and C-reactive protein (CRP) levels were measured. Postoperative pain was assessed following surgery. Neuropsychol. tests were performed before surgery, and 1 wk and 3 mo postoperation. Results: POCD incidence in group P was significantly lower compared with that of group C at 1 wk after surgery (16.7% vs 33.9%; P<0.05); no significant difference was found between groups C and P at 3-mo follow-up (9.7% vs 6.7%). Compared with group C values, visual analog pain scale (VAS) scores at 3, 6, and 12h after surgery were significantly lower in group P(P<0.05). Plasma IL-1β, IL-6, and TNF-α levels were lower in group P than in group C after the operation (P<0.05). No significant difference in the plasma CRP level was found between groups P and C. Conclusions: Parecoxib sodium decreases POCD incidence after total knee arthroplasty in elderly patients and may explain how this drug suppresses inflammation and acute postoperative pain caused by surgical trauma.
Medicine (Philadelphia, PA, United States) published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C38H74Cl2N2O4, Product Details of C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem