Zhou, Junyu published the artcileTherapeutic effect of parecoxib sodium on prevention of sore throat after laparoscopic cholecystectomy, Related Products of isoxazole, the publication is Jianyan Yixue Yu Linchuang (2021), 18(3), 368-371, database is CAplus.
Objective To observe the efficacy of parecoxib sodium in preventing postoperative sore throat after laparoscopic cholecystectomy. Methods A total of 130 patients with general anesthesia who underwent laparoscopic cholecystectomy from June 2018 to Jan. 2019 in Traditional Chinese Medicine Hospital of Beibei District were selected as research objects, and the patients were gender-specific, aged 21-67 years old, American society of anesthesiologists grade I, II, and were randomly divided into parecoxib sodium group (Group P) and saline group (Group S). Patients in group P received i.v. injection of parecoxib sodium 40 mg 10 min before the end of surgery, and patients in group S received an equal volum of normal saline. Visual analog scale/score (VAS) was recorded immediately after extubation, 2, 6, 12, and 24 h after surgery. The adverse reactions occurred during extubation were observed and recorded. The incidence of pharyngeal complications and the use of patient controlled i.v. analgesia (PCIA) at 6 h postoperatively, and QoR-15 (15-item quality of recovery scale) scores at 24, 48 h after surgery were recorded. Results VAS scores in the group P at the moment of extubation, 2, 6, and 12 h after surgery were lower than those in the group S, the number of PCIA compressions was less than that of the group S, the incidence of adverse reactions during extubation and complications in the throat at 6 h after surgery were significantly lower than those in group S, 15-item recovery quality scale scores at 24 and 48 h after surgery were significantly higher than that in group S, and the differences were statistically significant (P<0.05). Conclusion Parecoxib sodium can effectively reduce the incidence of sore throat after laparoscopic cholecystectomy.
Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C13H18N2, Related Products of isoxazole.
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https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem