Yu, Xue published the artcileParecoxib sodium influence of cognitive function after surgery for late-life depression rats experiment research, COA of Formula: C19H17N2NaO4S, the publication is Jianyan Yixue Yu Linchuang (2017), 14(18), 2735-2736, 2802, database is CAplus.
The paper was to study parecoxib sodium in elderly postoperative cognitive function in rats of depression, and improve treatment of senile depression. The 45 old rats as subjects, 15 were the normal control group, another 30 were established surgical model of depression in which inner 15 i.p. injection of 0.9% sodium chloride injection, i.p. injection of 15 Parry celecoxib sodium, open field, sucrose consumption test were used to assess depression, correlation detection method were used to evaluate postoperative cognitive changes related indicators. The water maze latency, space exploration time were (47.84 ± 10.56), (20.45 ± 5.67), parecoxib sodium group were (39.68 ± 6.73), (23.45 ± 5.89), parecoxib sodium group compared with the model group decreased significantly in the incubation period, and in space exploration to increase the time was significantly (P < 0.05); model group, IL-1β, IL-6, resp. (415.67 ± 23.45) ng/L, (79.96 ± 4.56) ng/L, parecoxib sodium group were (344.23 ± 23.14) ng/L, (70.45 ± 3.67) ng/L, parecoxib sodium group compared with the model group decreased significantly (P < 0.05). Also parecoxib sodium group compared with the model group increased in the horizontal and vertical movements significantly (P < 0.05), model group in sugar consumption, a significant increase compared with the sucrose preference parecoxib sodium group, in water consumption a significant reduction (P < 0.05). Parecoxib sodium could inhibit the expression of inflammatory cytokines in rat hippocampus to improve postoperative cognitive function.
Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H8N2, COA of Formula: C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem