Xu, Rui published the artcileStudy on determination of valdecoxib as major degradation impurity in parecoxib sodium by HPLC, Category: isoxazole, the publication is Zhongguo Weisheng Jianyan Zazhi (2014), 24(19), 2785-2786, 2790, database is CAplus.
A RP-HPLC method was established for the determination of the major degradation impurity and process impurities in parecoxib sodium. The separation was performed on a Phenomenex C18 column(150 mm*4.6 mm, 5μm). The mobile phase was acetonitrile-disodium hydrogen phosphate buffer solution(0.01 mol/L)(pH 3.0)(40:60, V/V). The detection was carried out with UV detector at 215 nm. The flow rate was 1.0 mL/min. The linear relationship between its major degradation impurity valdecoxib with the concentration of 0.5μg/mL∼5.0μg/mL and the response values of peak area was good, and the correlation coefficients were r=0.9997 and r=0.9992, resp. The average recovery was 100.2%±3.3%(n=9). The method was proved to be accurate, sensitive and reliable, which could be used for determination of the major degradation impurity valdecoxib in parecoxib sodium. The method was used to effectively control the quality of parecoxib.
Zhongguo Weisheng Jianyan Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C13H10O3, Category: isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem