C-H chlorination of (hetero)anilines via photo/organo co-catalysis was written by Xie, Wuchen;Wang, Meng;Yang, Siyu;Chen, Yadong;Feng, Jie;Huang, Yatian. And the article was included in Organic & Biomolecular Chemistry in 2022.Name: 3-(tert-Butyl)isoxazol-5-amine This article mentions the following:
Herein, a photo-redox and organo co-catalyzed chlorination method for anilines to gave chloro-anilines ArNR1R2 [Ar = 4-ClC6H4, 3,4-di-Cl-5-FC6H2, 4-Cl-2,5-di-FC6H2, etc.; R1 = H, Me; R2 = H, Me, C(O)Me, Ph, pyrimidin-2-yl; R1R2 = (CH2)2N(CH3)(CH2)2] was disclose. This method had great substrate generality and excellent mono-chlorination selectivity. Another merit of this method was the late-stage modification of drug mols., which would be useful in medicinal chem. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Name: 3-(tert-Butyl)isoxazol-5-amine).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Isoxazole can be synthesised via a variety of methods. Examples include via a 1,3-dipolar cycloaddition of nitrile oxides with alkynes.Name: 3-(tert-Butyl)isoxazol-5-amine
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem