The preparation of perfluoroaryl substituted isoxazoles via nucleophilic aromatic substitution with lithioalkylisoxazoles was written by Xia, Xiongbing;Knerr, Gary;Natale, N. R.. And the article was included in Journal of Heterocyclic Chemistry in 1992.Safety of 3-Methylisoxazole-5-acetic Acid This article mentions the following:
The lithioalkylisoxazoles obtained from C-5 lateral metalation of alkylisoxazoles I [R = H, R1 = H, CO2H; R2 = H, CON(CHMe2)2, 3-(crown ether)-substituted Pr, R3 = Me, Ph] add to hexafluorobenzene. When the C-4 substituent is an electron-withdrawing tertiary amide moiety, the yields are highest for mono-perfluoroarylation to give 5-[(pentafluorophenyl)methyl]isoxazoles I (R = C6F5). In the experiment, the researchers used many compounds, for example, 3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0Safety of 3-Methylisoxazole-5-acetic Acid).
3-Methylisoxazole-5-acetic Acid (cas: 19668-85-0) belongs to isoxazole derivatives. Isoxazoles present in various natural products and synthetic compounds of biological importance like antibacterial, antagonists, antiinflammatory, analgesics, and also show the applications in functional materials. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Safety of 3-Methylisoxazole-5-acetic Acid
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem