Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Chloropyridine-2-boronic Acid, is researched, Molecular C5H5BClNO2, CAS is 652148-90-8, about Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.Application of 652148-90-8.
Rhodium-catalyzed asym. Suzuki-Miyaura reaction of boronic acids with important partners including aryls, vinyls and heterocycles was reported to yield corresponding highly enantioenriched products. Further, it was showed that, Suzuki-Miyaura reaction of pyridine boronic acids were unsuitable, but they could be halogen-modified at the 2-position to undergo reaction and this halogen could then be removed or used to facilitate further reactions. The method was also used to synthesize isoanabasine, preclamol and niraparib an anticancer agent in several clin. trials. This method will be a useful tool in drug synthesis and discovery.
There is still a lot of research devoted to this compound(SMILES：OB(C1=NC(Cl)=CC=C1)O)Application of 652148-90-8, and with the development of science, more effects of this compound(652148-90-8) can be discovered.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem