Name: 3,5-Dimethyl-4-nitropyridine 1-oxide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about Systematic coordination chemistry and cytotoxicity of copper(II) complexes with methyl substituted 4-nitropyridine N-oxides. Author is Puszko, Aniela; Brzuszkiewicz, Anna; Jezierska, Julia; Adach, Anna; Wietrzyk, Joanna; Filip, Beata; Pelczynska, Marzena; Cieslak-Golonka, Maria.
Three new nitrato Cu(II) complexes of di-Me substituted 4-nitropyridine N-oxide were synthesized and characterized by elemental anal., magnetic, spectroscopic, thermal and x-ray methods, resp. They were isolated as trans isomers, mononuclear (μ = 1.70-1.88 μB), five-(1-2) and four-(3) coordinate species [Cu(NO3)2(H2O)L2] where L = 2,3-dimethyl- or 2,5-dimethyl-4-nitropyridine N-oxide and [Cu(NO3)2L2], L = 3,5-dimethyl-4-nitropyridine N-oxide, resp. The x-ray crystal structure of (1) (L = 2,3-dimethyl-4-nitropyridine N-oxide) was determined The organic ligands, the complexes and copper hexaqua ion as a reference were tested in vitro on the cytotoxic activity against human cancer cell lines: MCF-7 (breast), SW-707 (colon) and P-388 (murine leukemia). The complexes are relatively strong cytotoxic agents towards P-388 cell line. Comparative anal. was performed for all known Cu(II) complexes containing Me derivatives of the 4-nitropyridine N-oxide from their composition, structure and cytotoxic activities. To obtain the typical structure for these species (i.e., 4-coordinate mononuclear trans-[Cu(inorganic anion)2L2]), two Me groups must be situated on both sides of N atom(s) (i.e., NO and NO2) in the ligand. The biol. activity is strongly dependent upon the number of the Me groups and the type of cell line. The best cytotoxic results were found for the complexes without substituents or with one Me group. Generally, for all cell lines, the complexation increased cytotoxicity when compared with the free ligands.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem