Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2402-95-1, is researched, Molecular C5H4ClNO, about Research on synthesis of 2-chloro-4-nitropyridine-N-oxide, the main research direction is chloronitropyridine oxide synthesis chloropyridine oxidation mixed acid nitrification.Quality Control of 2-Chloropyridine 1-oxide.
2-Chloro-4-nitropyridine-N-oxide was synthesized from 2-chloropyridine by N-oxidation and mixed acid nitrifying with one pot reaction. The intermediate yield of 2-chloropyridine-N-oxide was 96.5% when n(2-chloropyridine):n(H2O2):n(CH3COOH) = 1:3.5:1.5, the reaction temperature was 80°C and the reaction time was 3 h. Synthetic liquid proceeded nitration reaction directly after enrichment. The production yield of 2-chloro-4-nitropyridine-N-oxide was 85.8% when n(2-chloropyridine-N-oxide):n(HNO3) = 1:3.5, V(H2SO4)/V(HNO3) = 1:1, the reaction temperature was 80°C and the reaction time was 6 h. The structures of intermediate and target product were confirmed by M.p., IR, MS and elemental anal. The final product was gained.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem