Vereshchagin, Anatoly N. published the artcileHighly diastereoselective amine-catalyzed Knoevenagel-Michael cyclization-ring opening cascade between aldehydes, 3-arylisoxazol-5(4H)-ones and 3-aminocyclohex-2-en-1-ones, Name: 3-Phenylisoxazol-5(2H)-one, the publication is Molecular Diversity (2018), 22(3), 627-636, database is CAplus and MEDLINE.
A highly diastereoselective three-component cascade reaction among aromatic aldehydes R1CHO (R1 = Ph, 4-ClC6H4, 4-O2NC6H4, 4-MeC6H4, 4-MeOC6H4), 3-arylisoxazol-5(4H)-ones (aryl = R2 = Ph, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) and 3-aminocyclohex-2-en-1-ones I (R3 = H, Me; R4 = H, PhCH2) took place under the catalysis with triethylamine to provide the corresponding hydroxyimino-functionalized tetrahydroquinolinediones II in 45-85% yields. The transformation presumably proceeds through a sequential cascade of Knoevenagel/Michael addition/cyclization/ring opening reactions. This process was carried out in green media (EtOH/water, 1:1-1:3) at reflux. Products were crystallized directly from the reaction mixture and their isolation includes only filtration. The structure of tetrahydroquinolinedione I (R1 = R2 = Ph; R3 = Me; R4 = H) was confirmed by X-ray diffraction anal.
Molecular Diversity published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C10H12F6N4O6PdS2, Name: 3-Phenylisoxazol-5(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem