One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Mofezolac, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 78967-07-4, Name is Mofezolac, molecular formula is C19H17NO5
We demonstrated recently that mofezolac, a cyclooxygenase-1 (COX-1) selective inhibitor, suppresses the development of azoxymethane (AOM)-induced colonic aberrant crypt foci in F344 rats and intestinal polyps in APC1309 mice. In the present study, we therefore investigated the effects of mofezolac on colon cancer development. Male F344 rats were injected subcutaneously with 15 mg/kg body weight of AOM in the back twice at 7-day intervals from 5 weeks of age, and fed a diet containing 600 or 1200 ppm mofezolac for 32 weeks, starting 1 day before the first dosing of AOM. Treatment with 1200 ppm mofezolac significantly reduced the incidence, multiplicity and volume of colon carcinomas to 79%, 2.15 ± 1.65 and 7.5 ± 11.8.mm 3, respectively, compared with 94%, 3.19 ± 1.87 and 23.7 ± 31.2.mm 3 in the AOM treatment alone. Administration of 600.ppm mofezolac showed only a slight reduction. No side effects were observed in any of the groups. These results confirm that COX-1, as well as COX-2, contributes to colon carcinogenesis and that mofezolac may be a good chemopreventive agent for human colon cancer.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of Mofezolac, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 78967-07-4
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem