Related Products of 288-14-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 288-14-2, Isoxazole, introducing its new discovery.
Currently, there are more than 65 million people at risk of contracting sleeping sickness caused by Trypanosoma brucei. Available treatments for this parasitic disease are limited and have side effects. There is a necessity to investigate novel, effective compounds that also yield low in toxicity. Quantitative Structure-Activity Relationship models (QSAR) have been used in this study for predicting anti-Trypanosoma brucei activity and potency in a group of dicationic 3,5-Diphenylisoxazoles. Linear Discriminant Analysis (LDA) correctly classified anti-Trypanosoma brucei activity in 100 % of cases (sensitivity) and inactivity in 86.7 % (specificity). Theoretical bioactivity (pIC50) of the studied compounds was predicted using Multilinear Regression Analysis (MLRA), demonstrating a high correlation between in vitro and in silico results (r2=0.82). Topologic models obtained with LDA and MLRA were applied to the screening of a group of dicationic analogs which presented a high in silico activity. These compounds when selected for in vitro analysis could reduce both time and costs in future drug research.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 288-14-2. In my other articles, you can also check out more blogs about 288-14-2
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem