One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 97925-43-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 97925-43-4, Name is 4-Bromoisoxazole, molecular formula is C3H2BrNO
Design, synthesis and biological evaluation of novel 4-alkynyl-quinoline derivatives as PI3K/mTOR dual inhibitors
Abstract A novel series of 4-alkynyl-quinoline derivatives were designed, synthesized and biologically evaluated for their PI3Kalpha inhibitory activities and anti-proliferative effects against two cancer cell lines PC-3 and HCT-116. Most of them showed potent PI3Kalpha inhibitory activities with IC50 values at low nanomolar level and good to excellent anti-proliferative effects against both cell lines. Among them, compound 15d, the most potent one, was selected for further biological evaluation. As a result, 15d displayed strong inhibitory activity against other class I PI3K isoforms (PI3Kbeta, PI3Kgamma and PI3Kdelta) and mTOR with an acceptable kinase selectivity profile. Moreover, the western blot assay indicated that the phosphorylation of Akt, another downstream effector of PI3K, can be remarkably suppressed by 15d at cellular level. All these experimental results suggested that 15d is a potent PI3K/mTOR dual inhibitor and could serve as a promising lead compound for the development of anticancer agents.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem