33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, belongs to isoxazole compound, is a common compound. category: IsoxazolesIn an article, once mentioned the new application about 33282-15-4.
O-alkylation of N-phenylhydroxylamine in dimethyl sulfoxide with methylarenesulfonates
The methylation of N-phenylhydroxylamine (NPHA) with methylarenesulfonates in DMSO gives alkylation of the O atom in contrast to methylation in methanol where N alkylation occurs. The Hammett p values indicate that alkylations with N-methylanilines and NPHAs both involve the N atom. The NPHAs show “nominal alpha-effects” but involve comparison of N atoms with O atoms. The reactivity of the principle component, the zwitterion I, is examined with leaving group studies and comparison with benzyl alkoxide reactivity.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem