Category: isoxazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Piperidineacetic Acid, is researched, Molecular C7H13NO2, CAS is 3235-67-4, about Difference spectra of P-450 in rat liver microsomes induced by piperidine N-derivatives and the spectral dissociation constant of each derivative. Author is Kimura, Katsuhiko; Nagaoka, Masao; Ohgiya, Shozaburo.
Piperidinoacetic acid [3235-67-4], N-cinnamylpiperidine [70552-70-4] and 3-piperidino-1-phenyl-1-propanone [73-63-2] caused type I spectral changes of cytochrome P-450 [9035-51-2] in reaction with the rat liver microsomes, whereas N-methylpiperidine (I) [626-67-5] caused type II spectral change. 2-Piperidinoethanol [3040-44-6] caused a modified type II spectral change. The apparent dissociation constants calculated from spectral changes for varying concentrations of the above compounds were in close correlation with the rates of N-C cleavage of those compounds by the microsomes.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem