Tao, Guanghua published the artcileApplication of dexmedetomidine combined with parecoxib sodium in pulmonary lobectomy with one-lung ventilation, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jianyan Yixue Yu Linchuang (2016), 13(23), 3348-3351, database is CAplus.
Objective: To investigate the effect of dexmedetomidine combined with parecoxib sodium on pulmonary inflammatory response in patients undergoing pulmonary lobectomy with one-lung ventilation. Methods: Eighty patients underwent pulmonary lobectomy with one-lung ventilation were randomly divided into dexmedetomidine group (group D, n = 20), parecoxib sodium group (group P, n = 20), dexmedetomidine combined with parecoxib sodium group (D + P group, n = 20) and saline control group (N group, n = 20). The groups were treated with normal saline, dexmedetomidine, parecoxib sodium and dexmedetomidine combined with parecoxib sodium, resp. Peripheral venous blood was taken from the patients, and levels of interleukin (IL)-1β, IL-6, cyclooxygenase-2 (COX-2), reactive oxygen species (ROS) at different time points were detected by ELISA immunoassay. Radial arterial blood was taken from the patients and analyzed, and the partial pressure of blood oxygen (PaO2), partial pressure of carbon dioxide (PaCO2) and oxygenation index were compared. VAS pain score and analgesic dose were recorded at 12 h and 24 h after surgery. Results: The expression of inflammatory factors in D + P group was significantly lower than that in other groups, and that of the D group and P group were significantly less than that of N group (P < 0.05). The blood gas anal. showed that PaO2 and oxygenation index in the D + P group were higher than those of the N group, while PaCO2 is lower, and there is no statistically significant difference between the P group and D group (P > 0.05). In comparison of VAS score and 24 h tramadol dosage, the D + P group had the lowest VAS score and tramadol dosage, which were significantly lower than those of the N group (P < 0.05). Conclusion: Dexmedetomidine combined with parecoxib sodium can reduce intraoperative pulmonary inflammatory response, improve oxygenation and reduce the dose of postoperative analgesics in patients undergoing pulmonary lobectomy with one-lung ventilation.
Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H8O3, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem