Stivanin, Mateus L.’s team published research in Journal of Organic Chemistry in 82 | CAS: 1076-59-1

Journal of Organic Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C8H14O4, Synthetic Route of 1076-59-1.

Stivanin, Mateus L. published the artcileAn Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights, Synthetic Route of 1076-59-1, the publication is Journal of Organic Chemistry (2017), 82(19), 10319-10330, database is CAplus and MEDLINE.

A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines, e.g., I (X-rays single crystal structure shown), is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.

Journal of Organic Chemistry published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C8H14O4, Synthetic Route of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem